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KMID : 1171820060210030044
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Journal of Environmental and Sanitary Engineering
2006 Volume.21 No. 3 p.44 ~ p.51
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Effect of Rubus coreanum Extracts on Tyrosinase Promoter
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Chin Jong-Eon
Cho Nam-Chul
Kim Kwan-Chun
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Abstract
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To estimate the inhibitory effect of Rubus coreanum extract on melanin biosynthesis, we tested its inhibitory effects on tyrosinase promoter in B16 mouse melanoma cells. Rubus coreanum extract by methanol had inhibitory effect approximately 10% on tyrosinase promoter at 100 ㎍/mL. In the MTT assay, the same extract exhibited very low cytotoxicity under 100 ㎍/mL. The fractions of methylene chloride, butyl alcohol and water did not showed the inhibitory effect on tyrosinase promoter, but the fraction of ethyl acetate exhibited inhibitory effect approximately 11% at 100 ㎍/mL.
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KEYWORD
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Rubus coreanum, tyrosinase promoter, B16 mouse melanoma cell
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